Synthesis and evaluation of the antiinflammatory activity of N-[2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl]-nicotinamide.

Abstract	A new molecule incorporating nicotinoyl moiety, thiazolidin-4-one ring and 3,5-di-tert-butyl-4-hydroxyphenyl group (a potent antioxidant moiety) was synthesized and evaluated for anti-inflammatory activity in acute as well as chronic phase models of inflammation. The compound exhibited significant anti-inflammatory activity in three experimental models of inflammation, comparable to the positive control drug, ibuprofen (CAS 15687-27-1). It is suggested that besides the hypolipidemic and anti-oxidant potential of the molecule, its anti-inflammatory action could possibly act as an additional mechanism of its hypothesized anti-atherosclerotic activity.
Authors	Rajiv Kalia, Chamallamudi Mallikarjuna Rao, Nampurath Gopalan Kutty
Journal	Arzneimittel-Forschung (Arzneimittelforschung) Vol. 57 Issue 9 Pg. 616-22 ( 2007) ISSN: 0004-4172 [Print] Germany
PMID	17966761 (Publication Type: Journal Article)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Antioxidants Indicators and Reagents N-(2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl)-nicotinamide Niacinamide Copper Carrageenan Aspartate Aminotransferases Alanine Transaminase Ibuprofen
Topics	Alanine Transaminase (blood) Animals Anti-Inflammatory Agents, Non-Steroidal (chemical synthesis, pharmacology, toxicity) Antioxidants (chemical synthesis, pharmacology) Arthritis, Experimental (drug therapy, pathology) Aspartate Aminotransferases (blood) Atherosclerosis (prevention & control) Carrageenan Copper (blood) Dose-Response Relationship, Drug Drug Evaluation, Preclinical Edema (chemically induced, drug therapy, pathology) Granuloma (chemically induced, drug therapy, pathology) Ibuprofen (therapeutic use) Indicators and Reagents Inflammation (chemically induced, drug therapy) Male Niacinamide (analogs & derivatives, chemical synthesis, pharmacology) Rats Rats, Wistar

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