Exacerbation of paranoid schizophrenia in a psoriatic patient after treatment with cyclosporine A, but not with etanercept.

Psoriasis may be frequently associated with psychiatric diseases. We present a 44-year-old man undergoing cyclosporine therapy for treatment of generalized plaque psoriasis which exacerbated his symptoms of paranoid schizophrenia, and disappeared a few days after discontinuation of cyclosporine. Replacement therapy with etanercept achieved clinical remission of psoriasis without any psychiatric side effects. Systemic medications, such as cyclosporine and etanercept, induce modifications of the cytokine network. This is pathogenetically significant in both psoriasis and psychiatric disorders. This case report suggests that dermatologists need to become more familiar with the risk-benefit of drug-induced cytokines dysregulation in psoriatic patients with comorbid psychiatric disorders.
AuthorsSergio Di Nuzzo, Martina Zanni, Giuseppe De Panfilis
JournalJournal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 6 Issue 10 Pg. 1046-7 (Oct 2007) ISSN: 1545-9616 [Print] United States
PMID17966184 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Receptors, Tumor Necrosis Factor
  • Cyclosporine
  • Etanercept
  • Adult
  • Cyclosporine (adverse effects, therapeutic use)
  • Etanercept
  • Humans
  • Immunoglobulin G (therapeutic use)
  • Immunosuppressive Agents (adverse effects, therapeutic use)
  • Male
  • Psoriasis (complications, drug therapy)
  • Receptors, Tumor Necrosis Factor (therapeutic use)
  • Schizophrenia, Paranoid (chemically induced, complications)

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