HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Exacerbation of paranoid schizophrenia in a psoriatic patient after treatment with cyclosporine A, but not with etanercept.

Abstract
Psoriasis may be frequently associated with psychiatric diseases. We present a 44-year-old man undergoing cyclosporine therapy for treatment of generalized plaque psoriasis which exacerbated his symptoms of paranoid schizophrenia, and disappeared a few days after discontinuation of cyclosporine. Replacement therapy with etanercept achieved clinical remission of psoriasis without any psychiatric side effects. Systemic medications, such as cyclosporine and etanercept, induce modifications of the cytokine network. This is pathogenetically significant in both psoriasis and psychiatric disorders. This case report suggests that dermatologists need to become more familiar with the risk-benefit of drug-induced cytokines dysregulation in psoriatic patients with comorbid psychiatric disorders.
AuthorsSergio Di Nuzzo, Martina Zanni, Giuseppe De Panfilis
JournalJournal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 6 Issue 10 Pg. 1046-7 (Oct 2007) ISSN: 1545-9616 [Print] United States
PMID17966184 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Receptors, Tumor Necrosis Factor
  • Cyclosporine
  • Etanercept
Topics
  • Adult
  • Cyclosporine (adverse effects, therapeutic use)
  • Etanercept
  • Humans
  • Immunoglobulin G (therapeutic use)
  • Immunosuppressive Agents (adverse effects, therapeutic use)
  • Male
  • Psoriasis (complications, drug therapy)
  • Receptors, Tumor Necrosis Factor (therapeutic use)
  • Schizophrenia, Paranoid (chemically induced, complications)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: