| Abstract | ACE-inhibitor induced angioedema is a non-allergic drug-related side effect. Inhibited bradykinin degradation leads to an unphysiological enhanced bradykinin plasma level with vascular leakage and, consequently, to angioedema. ACE-inhibitor induced angioedema develop rapidly in the head and neck region. Typical sites of manifestation are lips, tongue, and larynx. Novel pharmacotherapies may allow a causal treatment of the ACE-inhibitor induced angioedema in the future. |
| Authors | M Bas, T K Hoffmann, G Kojda, H Bier
(Affiliation: Hals-Nasen-Ohrenklinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, München, Germany. basmurat at web.de)
|
| Journal | Laryngo- rhino- otologie
(Laryngorhinootologie)
Vol. 86
Issue 11
Pg. 804-8, quiz 809-13
(Nov 2007)
ISSN: 0935-8943 Germany |
| Vernacular Title | Das ACE-Hemmer-induzierte Angioödem. |
| PMID | 17966084
(Publication Type: English Abstract, Journal Article, Review)
|
| Chemical References |
- Adrenal Cortex Hormones
- Angiotensin-Converting Enzyme Inhibitors
- Histamine Antagonists
- Receptors, Bradykinin
- icatibant
- Bradykinin
|
| Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Algorithms
- Angioedema
(blood, chemically induced, diagnosis, drug therapy, physiopathology, radiography, therapy)
- Angioedema, Hereditary
(diagnosis)
- Angiotensin-Converting Enzyme Inhibitors
(adverse effects, pharmacology)
- Bradykinin
(analogs & derivatives, blood, physiology, therapeutic use)
- Forecasting
- Histamine Antagonists
(therapeutic use)
- Humans
- Laryngeal Edema
(chemically induced, diagnosis)
- Laryngoscopy
- Magnetic Resonance Imaging
- Receptors, Bradykinin
(antagonists & inhibitors)
- Time Factors
- Tomography, X-Ray Computed
|
