Abstract | OBJECTIVES: METHODS: RESULTS: LPS induced measurable cytokine expression for 14 of the 16 cytokines assayed. Besifloxacin significantly inhibited LPS-stimulated cytokine production in a dose-dependent manner, with a comparable [ granulocyte macrophage colony-stimulating factor ( GM-CSF), interleukin (IL)-1beta, IL-8, interferon-inducible protein (IP-10), monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha)] or better [granulocyte CSF ( G-CSF), IL-1alpha, IL-1 receptor antagonist (IL-1ra) and IL-6] potency compared with moxifloxacin. A significant inhibitory effect of besifloxacin was observed at 0.1 mg/L for IL-1alpha, at 1 mg/L for G-CSF, IL-1ra and IL-6 and at 30 mg/L for GM-CSF, IL-12p40, IL-1beta, IL-8, IP-10, MCP-1 and MIP-1alpha. CONCLUSIONS:
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Authors | Jin-Zhong Zhang, Keith W Ward |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 61
Issue 1
Pg. 111-6
(Jan 2008)
ISSN: 1460-2091 [Electronic] England |
PMID | 17965029
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Azepines
- Cytokines
- Fluoroquinolones
- Lipopolysaccharides
- besifloxacin
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Topics |
- Anti-Bacterial Agents
(chemistry, pharmacology)
- Anti-Inflammatory Agents, Non-Steroidal
(chemistry, pharmacology)
- Azepines
(chemistry, pharmacology)
- Cell Line
- Cytokines
(antagonists & inhibitors)
- Eye Infections
(drug therapy)
- Fluoroquinolones
(chemistry, pharmacology)
- Humans
- Lipopolysaccharides
(pharmacology)
- Molecular Structure
- Monocytes
(drug effects, immunology)
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