HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Deep vein thrombosis and fibrinolysis. Defective urokinase type plasminogen activator release.

Abstract
In the present study 57 consecutive patients with a first episode of venographically proven deep vein thrombosis were investigated to evaluate the release of tissue-type plasminogen activator (t-PA) and of urokinase-type plasminogen activator (u-PA) in response to DDAVP stimulation as well as the resting plasminogen activator inhibitor (PAI) concentration, comparing this to the results obtained in 66 similar patients with a clinical suspicion of thrombosis but with a normal venogram. All assays were performed without knowledge of the patient's status. Four patients in the deep vein thrombosis-group (7%) had an absent u-PA antigen response upon DDAVP infusion, while a normal response was observed in all control subjects. Patients and controls showed similar increases in t-PA antigen level upon DDAVP. High resting PAI antigen levels were encountered in 5 patients in the deep vein thrombosis-group (9%) and in 6 subjects in the control group (9%). The results from this controlled study indicate that a defective release of u-PA may occur in patients with deep vein thrombosis and may have pathogenetic significance. Furthermore it is concluded that elevation of PAI levels cannot be considered as a specific risk factor for venous thrombosis.
AuthorsM Levi, A W Lensing, H R Büller, P Prandoni, G Dooijewaard, S Cuppini, J W ten Cate
JournalThrombosis and haemostasis (Thromb Haemost) Vol. 66 Issue 4 Pg. 426-9 (Oct 1 1991) ISSN: 0340-6245 [Print] GERMANY
PMID1796391 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens
  • Plasminogen Inactivators
  • Tissue Plasminogen Activator
  • Urokinase-Type Plasminogen Activator
  • Deamino Arginine Vasopressin
Topics
  • Antigens (blood)
  • Deamino Arginine Vasopressin
  • Enzyme-Linked Immunosorbent Assay
  • Fibrinolysis (physiology)
  • Humans
  • Plasminogen Inactivators (immunology)
  • Prevalence
  • Reference Values
  • Retrospective Studies
  • Thrombophlebitis (blood)
  • Tissue Plasminogen Activator (immunology)
  • Urokinase-Type Plasminogen Activator (blood, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: