Deep vein thrombosis and fibrinolysis. Defective urokinase type plasminogen activator release.

In the present study 57 consecutive patients with a first episode of venographically proven deep vein thrombosis were investigated to evaluate the release of tissue-type plasminogen activator (t-PA) and of urokinase-type plasminogen activator (u-PA) in response to DDAVP stimulation as well as the resting plasminogen activator inhibitor (PAI) concentration, comparing this to the results obtained in 66 similar patients with a clinical suspicion of thrombosis but with a normal venogram. All assays were performed without knowledge of the patient's status. Four patients in the deep vein thrombosis-group (7%) had an absent u-PA antigen response upon DDAVP infusion, while a normal response was observed in all control subjects. Patients and controls showed similar increases in t-PA antigen level upon DDAVP. High resting PAI antigen levels were encountered in 5 patients in the deep vein thrombosis-group (9%) and in 6 subjects in the control group (9%). The results from this controlled study indicate that a defective release of u-PA may occur in patients with deep vein thrombosis and may have pathogenetic significance. Furthermore it is concluded that elevation of PAI levels cannot be considered as a specific risk factor for venous thrombosis.
AuthorsM Levi, A W Lensing, H R Büller, P Prandoni, G Dooijewaard, S Cuppini, J W ten Cate
JournalThrombosis and haemostasis (Thromb Haemost) Vol. 66 Issue 4 Pg. 426-9 (Oct 1 1991) ISSN: 0340-6245 [Print] GERMANY
PMID1796391 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens
  • Plasminogen Inactivators
  • Tissue Plasminogen Activator
  • Urokinase-Type Plasminogen Activator
  • Deamino Arginine Vasopressin
  • Antigens (blood)
  • Deamino Arginine Vasopressin
  • Enzyme-Linked Immunosorbent Assay
  • Fibrinolysis (physiology)
  • Humans
  • Plasminogen Inactivators (immunology)
  • Prevalence
  • Reference Values
  • Retrospective Studies
  • Thrombophlebitis (blood)
  • Tissue Plasminogen Activator (immunology)
  • Urokinase-Type Plasminogen Activator (blood, immunology)

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