[Protective effect of hepatic stimulator substance against experimental acute liver failure in mice].

Abstract

A hepatic stimulator substance (HSS) was extracted from the liver of male weanling SD rats according to the method of LaBrecque. The mice were injected with carbon tetrachloride or D-galactosamine to induce hepatic injuries and the protective effect of HSS on thus induced hepatic damage was investigated. The results were as follows: (1) HSS could suppresses the elevation of sGPT and sGOT induced by carbon tetrachloride intoxication in a dose-dependent manner. (2) Hepatic histological findings indicated that the degree of CCl4 or D-galactosamine-induced hepatic lesions could be lessened by HSS. (3) CCl4-induced reduction of hepatic mitochondrial succinic dehydrogenase activity could be restored by HSS. (4) Insulin-glucagon enhanced the survival of D-galactosamine intoxicated mice and stimulated hepatocyte proliferation, thus showing less pronounced hepatic damage.

• Authors: W An, M H Mei
• Journal: Sheng li xue bao : [Acta physiologica Sinica] (Sheng Li Xue Bao) Vol. 43 Issue 5 Pg. 415-27 (Oct 1991) ISSN: 0371-0874 [Print] China
• PMID: 1796305 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Activating Transcription Factor 3
• DNA-Binding Proteins
• Insulin
• liver regeneration factor 1
• Galactosamine
• Glucagon
• Succinate Dehydrogenase

Topics

• Activating Transcription Factor 3
• Animals
• Carbon Tetrachloride Poisoning (pathology, prevention & control)
• Chemical and Drug Induced Liver Injury (etiology, pathology, prevention & control)
• DNA-Binding Proteins (therapeutic use)
• Galactosamine
• Glucagon (pharmacology)
• Insulin (pharmacology)
• Leucine Zippers
• Liver Regeneration
• Male
• Mice
• Rats
• Rats, Inbred Strains
• Succinate Dehydrogenase (metabolism)