Tourette's syndrome is not associated with interleukin-10 receptor 1 variants on chromosome 11q23.3.

Abstract

Interleukin-10 receptor 1 (IL-10R1) single nucleotide polymorphisms, located on chromosome 11q23 - a strong candidate for linkage with Tourette's syndrome (TS) - have been investigated for association with TS. DNA of 77 patients with a DSM-IV (Diagnostic and Statistical Manual IV) diagnosis of TS and 250 healthy controls was genotyped. IL-10R1 was not associated with TS.

• Authors: Jochen Kindler, Alexandra Schosser, Mara Stamenkovic, Monika Schloegelhofer, Friedrich Leisch, Kurt Hornik, Harald Aschauer, Christoph Gasche
• Journal: Psychiatry research (Psychiatry Res) Vol. 157 Issue 1-3 Pg. 235-9 (Jan 15 2008) ISSN: 0165-1781 [Print] Ireland
• PMID: 17961716 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• Interleukin-10 Receptor alpha Subunit

Topics

• Adult
• Alleles
• Autoantibodies (immunology)
• Chromosomes, Human, Pair 11 (genetics)
• Female
• Genotype
• Humans
• Interleukin-10 Receptor alpha Subunit (genetics, immunology)
• Male
• Polymerase Chain Reaction
• Tourette Syndrome (genetics, immunology)