| Abstract | OBJECTIVE: To evaluate the efficacy and safety of glucosamine hydrochloride for the treatment of osteoarthritis. METHODS: A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride comparing glucosamine sulfate for the treatment of osteoarthritis was performed. One hundred and forty-three patients suffering from knee or hip osteoarthritis were randomized into study (glucosamine hydrochloride) or control (glucosamine sulfate) group. Patients in study group orally took glucosamine hydrochloride 2 times daily for 6 weeks, each time 1 capsule, and those in control group took glucosamine sulfate 3 times daily for 6 weeks also, each time 2 capsules. RESULTS: The symptomatic improvement of joint pain at walking, at rest and stiffness after 6 week treatment with glucosamine hydrochloride was better than those with glucosamine sulfate. The results had significant difference (P < 0.05). Total effective rates of patients with glucosamine hydrochloride was 75.4% and 60.6% with glucosamine sulfate, but no statistical difference. The results suggested both glucosamine had the considerable efficacy in the treatment of osteoarthritis. Three cases in study group and 2 in control group reported mild adverse events. No severe adverse events (SAE) was observed. CONCLUSION: Glucosamine hydrochloride is as effective and safe as glucosamine sulfate for the treatment of osteoarthritis. |
| Authors | Wei-bin Zhang, Cheng-yu Zhuang, Jian-min Li, Zhi-ping Yang, Xiao-liang Chen
(Affiliation: Department of Orthopedics, Rui Jin Hospital, Shanghai Jiao Tong University Medical College, Shanghai 200025, China. weibin at medmail.com.cn)
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| Journal | Zhonghua wai ke za zhi [Chinese journal of surgery]
(Zhonghua Wai Ke Za Zhi)
Vol. 45
Issue 14
Pg. 998-1001
(Jul 15 2007)
ISSN: 0529-5815 China |
| PMID | 17961392
(Publication Type: English Abstract, Journal Article)
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