Abstract | INTRODUCTION: AIM: METHODS: RESULTS:
Testosterone and SHBG levels for patients 1, 2, and 3, respectively: total testosterone 183, 71, and 151 ng/dL (260-1,000 ng/dL); free testosterone (not done for patient 3) 58.3 and 26.9 pg/mL (50-210 pg/mL); SHBG 6, 9, and 6 nmol/L (7-50 nmol/L). No other hormonal abnormalities were detected. Following discontinuation of oxandrolone, levels of total testosterone rose, consistent with increase in SHBG. One patient received repeat SHBG assay documenting rise in SHBG level. Patient 2 reported return of libido and early morning erections several weeks after discontinuation of oxandrolone. CONCLUSIONS: Patients had erectile dysfunction in association with low testosterone and SHBG, in spite of exogenous testosterone replacement. Discontinuation of oxandrolone led to the normalization or improvement of testosterone levels in all three patients with symptomatic improvement in one patient. First pass metabolism of orally administered oxandrolone may decrease hepatic synthesis of SHBG, allowing exogenously supplied testosterone to be excreted. Further work is necessary to elucidate the relationship.
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Authors | Peter Wasserman, Sorana Segal-Maurer, David Rubin |
Journal | The journal of sexual medicine
(J Sex Med)
Vol. 5
Issue 1
Pg. 241-7
(Jan 2008)
ISSN: 1743-6095 [Print] Netherlands |
PMID | 17961146
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Androgens
- Sex Hormone-Binding Globulin
- Testosterone
- Oxandrolone
- testosterone enanthate
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Topics |
- Adult
- Androgens
(administration & dosage, adverse effects)
- Antiretroviral Therapy, Highly Active
(adverse effects)
- Drug Therapy, Combination
- Erectile Dysfunction
(chemically induced, prevention & control)
- HIV Infections
(complications, drug therapy)
- Humans
- Hypogonadism
(complications, drug therapy)
- Male
- Middle Aged
- Oxandrolone
(administration & dosage, adverse effects)
- Sex Hormone-Binding Globulin
(drug effects, metabolism)
- Testosterone
(administration & dosage, analogs & derivatives, metabolism)
- Treatment Outcome
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