Abstract | BACKGROUND: In a previous study, we found that thrombin induced proliferation of TM-1 and T98G human glioma cells and that the mitogenic effect was abolished by hirudin. OBJECTIVES: METHODS: RESULTS: CONCLUSIONS: These results indicate that thrombin may play an important role in the proliferation of A172 cells by inducing PDGF-AB secretion and that thrombin's action is mediated by its proteolytic activity. Inhibition of thrombin's proteolytic activity may be a new therapeutic method for gliomas.
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Authors | Y Hayakawa, M Kurimoto, S Nagai, K Kurosaki, Y Tsuboi, H Hamada, N Hayashi, S Endo |
Journal | Journal of thrombosis and haemostasis : JTH
(J Thromb Haemost)
Vol. 5
Issue 11
Pg. 2219-26
(Nov 2007)
ISSN: 1538-7933 [Print] England |
PMID | 17958740
(Publication Type: Journal Article)
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Chemical References |
- Culture Media, Conditioned
- Platelet-Derived Growth Factor
- Proto-Oncogene Proteins c-sis
- RNA, Messenger
- platelet-derived growth factor AB
- Heparin Cofactor II
- Thrombin
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Topics |
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Culture Media, Conditioned
(chemistry)
- Glioblastoma
(metabolism, pathology)
- Heparin Cofactor II
(administration & dosage, pharmacology)
- Humans
- Platelet-Derived Growth Factor
(metabolism)
- Proto-Oncogene Proteins c-sis
(analysis, genetics)
- RNA, Messenger
(analysis)
- Thrombin
(pharmacology)
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