To investigate the anti-
tumor and side effect of
CpG ODN 1826 and CpG
ODN2006 as an adjuvants on leukemic
tumor in mouse-models, an acute lymphocytic leukemic
tumor in mouse model was established, then inoculated inactivated L1210 cells alone or with different
vaccine adjuvants were injected subcutaneously into each DBA/2 model mouse at different times. The activities of mice, the
tumor formation rate and the growth status of leukemic
tumor were observed. The
tumor was examined by pathologic section. The results showed that the
vaccine of inactivated L1210 cells and
CpG ODN 1826 could decrease the leukemic
tumor formation rate, slow down the growth of leukemic
tumor mass in mice and obviously cause
necrosis of
tumor cells, but it could not prolong the life spans of the
tumor-burden mice; while CpG
ODN2006 could not only decrease the
tumor formation rate, slow down the growth of
tumor mass in mice and result in obvious
necrosis of
tumor cells, but also could eliminate the existing
tumor mass in mice, and prolong the life spans of the
tumor-burden mice. It is concluded that using CpG
ODN2006 as an adjuvant enhances the anti-
tumor effect against the leukemic
tumor, prolong the life span of
tumor-burden mice without obvious side effect.