Abstract | OBJECTIVE: METHODS: A cross-sectional study was carried out in 48 women with GDM and 23 healthy pregnant women. Urinary levels of P-IPG were assessed spectrophotometrically by the activation of pyruvate dehydrogenase phosphatase in urinary specimens and correlated with clinical parameters. RESULTS: Urinary excretion of P-IPG was higher in GDM than in control women (312.1 +/- 151.0 vs. 210.6 +/- 82.7 nmol NADH/min/mg creatinine, P < 0.01) with values increasing throughout pregnancy in control subjects (r2 = 0.34, P < 0.01). P-IPG correlated with blood glucose levels (r(2) = 0.39, P < 0.01 for postprandial glycaemia and r2 = 0.18 P < 0.01 for mean glycaemia) and birthweight in the diabetic group (r2 = 0.14, P < 0.01). CONCLUSIONS: Increased P-IPG urinary excretion occurs in GDM and positively correlates with blood glucose levels. P-IPG may play a role in maternal glycaemic control and, possibly, fetal growth in GDM.
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Authors | M Scioscia, S Kunjara, K Gumaa, P McLean, C H Rodeck, T W Rademacher |
Journal | Diabetic medicine : a journal of the British Diabetic Association
(Diabet Med)
Vol. 24
Issue 11
Pg. 1300-4
(Nov 2007)
ISSN: 0742-3071 [Print] England |
PMID | 17956457
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Inositol Phosphates
- Polysaccharides
- inositol phosphate glycan
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Topics |
- Adult
- Blood Glucose
(metabolism)
- Cross-Sectional Studies
- Diabetes, Gestational
(diagnosis)
- Female
- Humans
- Infant, Newborn
- Inositol Phosphates
(urine)
- London
- Polysaccharides
(urine)
- Pregnancy
- Risk Factors
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