HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Novel agents for cancer prevention based on nitric oxide.

Abstract
NO (nitric oxide) biology has provided the impetus for the development of anticancer agents based on their ability to release NO. NO-NSAIDs (NO-donating non-steroidal anti-inflammatory drugs), consisting of a conventional NSAID to which an NO-releasing moiety is covalently attached, are promising chemopreventive agents against cancer. Compared with their parent compounds, NO-NSAIDs are up to several hundred times more potent in inhibiting the growth of cancer cell lines and prevent colon and pancreatic cancer in animal models. Their chemopreventive effect is due to inhibition of proliferation, induction of cell death and inhibition of cell-cycle-phase transitions. NO-ASA (NO-aspirin), the best-studied NO-NSAID, induces oxidative stress in target cells. Major downstream signalling effects involve the Wnt, NOS2 (nitric oxide synthase 2), MAPK (mitogen-activated protein kinase), NF-kappaB (nuclear factor kappaB) and Nrf2 (nuclear factor-erythroid 2 p45 subunit-related factor 2) pathways. NO-NSAIDs, particularly NO-ASA, appear to be safe compounds, as suggested by many animal and early human studies. An ongoing clinical trial is designed to determine whether NO-ASA can inhibit early stages of colon carcinogenesis in subjects at risk for colon cancer. It is clinical trials that will ultimately determine the role of NO-NSAIDs in cancer prevention and perhaps treatment.
AuthorsB Rigas
JournalBiochemical Society transactions (Biochem Soc Trans) Vol. 35 Issue Pt 5 Pg. 1364-8 (Nov 2007) ISSN: 0300-5127 [Print] England
PMID17956352 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticarcinogenic Agents
  • Nitric Oxide Donors
  • Nitric Oxide
Topics
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Anticarcinogenic Agents (pharmacology)
  • Humans
  • Neoplasms (prevention & control)
  • Nitric Oxide (pharmacology)
  • Nitric Oxide Donors (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: