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Immunological upgrading with combined immunotherapy and chemotherapy in a lepromatous leprosy patient: a case report.

Abstract
Immunotherapy with Mycobacterium w was given, in addition to standard multidrug therapy (MDT) to a lepromatous leprosy (LL) patient with a bacteriological index (BI) of 6. After 15 months of treatment this patient attained bacteriological negativity and clinical inactivity. Histopathologically the patient upgraded to borderline-tuberculoid at 12 months, and at 15 months showed features of nonspecific infiltration in the dermis. The rapid immunological upgrading seen in the patient is highlighted in this paper.
AuthorsS A Zaheer, N R Suresh, H K Kar, A K Sharma, A Mukherjee, R Mukherjee, G P Talwar
JournalLeprosy review (Lepr Rev) Vol. 62 Issue 3 Pg. 297-302 (Sep 1991) ISSN: 0305-7518 [Print] England
PMID1795588 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Bacterial Vaccines
  • Leprostatic Agents
  • anti-leprosy vaccine
  • Lepromin
Topics
  • Bacterial Vaccines (therapeutic use)
  • Combined Modality Therapy
  • Drug Therapy, Combination
  • Humans
  • Lepromin (immunology)
  • Leprostatic Agents (administration & dosage)
  • Leprosy, Lepromatous (immunology, pathology, therapy)
  • Male
  • Middle Aged
  • Mycobacterium leprae (immunology)

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