Effects of ciprofloxacin/dexamethasone and ofloxacin on tympanic membrane perforation healing.

Abstract

HYPOTHESIS:

Exposure to ciprofloxacin/dexamethasone, but not ofloxacin, prolongs tympanic membrane (TM) healing.

BACKGROUND:

Exposure to hydrocortisone has been shown to delay TM wound healing. No published studies have compared the effects of ciprofloxacin/dexamethasone and ofloxacin on TM healing.

METHODS:

Noninfected TM perforations were created in 30 rats. The rats were split into three groups, and ciprofloxacin/dexamethasone, ofloxacin, or isotonic sodium chloride solution drops were instilled for 8 days. Tympanic membrane healing was analyzed at specified intervals using photographic documentation verified by a blinded observer.

RESULTS:

The isotonic sodium chloride solution control and ofloxacin-exposed TMs healed at similar rates. There was a statistically significant delay in TM healing in the ciprofloxacin-/dexamethasone-exposed TMs by postoperative Day 10. However, all TM perforations were healed by postoperative Day 20.

CONCLUSION:

Ciprofloxacin/dexamethasone delays healing of experimental TM perforations, but the brief exposure in this study did not cause persistent perforations.

• Authors: Jeffrey Buyten, Galen Kaufman, Matthew Ryan
• Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology (Otol Neurotol) Vol. 28 Issue 7 Pg. 887-90 (Oct 2007) ISSN: 1531-7129 [Print] United States
• PMID: 17955604 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Anti-Inflammatory Agents
• Ciprofloxacin
• Dexamethasone
• Ofloxacin

Topics

• Animals
• Anti-Bacterial Agents (adverse effects, pharmacokinetics)
• Anti-Inflammatory Agents (adverse effects, pharmacokinetics)
• Ciprofloxacin (adverse effects, pharmacokinetics)
• Dexamethasone (adverse effects, pharmacokinetics)
• Ofloxacin (adverse effects)
• Rats
• Rats, Sprague-Dawley
• Tympanic Membrane (pathology)
• Tympanic Membrane Perforation (pathology)
• Wound Healing (drug effects)