Treatment of drop attacks in Coffin-Lowry syndrome with the use of sodium oxybate.

Abstract

Coffin-Lowry syndrome is a well-defined clinical entity classically associated with moderate to severe mental retardation, characteristic facial features, skeletal deformities, and tapering fingers. A characteristic paroxysmal disorder was described in up to 10% patients with Coffin-Lowry syndrome, characterized by sudden loss of muscle tone induced by unexpected tactile or auditory stimuli. These events were given several names, including cataplexy, nonepileptic collapses with atonia, exaggerated startle responses, hyperekplexia, and stimulus-induced drop episodes. Various therapies were undertaken for these drop attacks, including clonazepam, tiagabine, felbamate, selective serotonin reuptake inhibitors, and tricyclics, with variable improvement. We report on a 22-year-old man with Coffin-Lowry syndrome with stimulus-induced drop episodes, who failed therapy with clonazepam, several antiepileptic drugs, and escitalopram, and who was given a trial of sodium oxybate with complete resolution of the drop attacks.

• Authors: Navasuma Havaligi, Chandra Matadeen-Ali, Divya S Khurana, Harold Marks, Sanjeev V Kothare
• Journal: Pediatric neurology (Pediatr Neurol) Vol. 37 Issue 5 Pg. 373-4 (Nov 2007) ISSN: 0887-8994 [Print] United States
• PMID: 17950427 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anesthetics, Intravenous
• Sodium Oxybate

Topics

• Adult
• Anesthetics, Intravenous (therapeutic use)
• Coffin-Lowry Syndrome (complications)
• Humans
• Male
• Sodium Oxybate (therapeutic use)
• Syncope (drug therapy, etiology)