[Protective effect of antioxidants in methemoglobinemia caused by sodium nitrite in experimental studies].

Abstract

Sodium nitrite induced poisoning resulted into oxidation-reduction disorders with concomitant changes in the ratio of the oxidated and reduced forms towards accumulation of the oxidated equivalents. Antioxidants unithiol, tocopherol acetate, ascorbic acid, methylene blue, violuric acid influenced the oxidation-reduction balance in different ways. The protective action of violuric acid was comparable with that of methylene blue and exceeded the unithiol protective properties. Violuric acid, as compared with unithiol, ascorbic acid and tocopherol, was more effective in decreasing methemoglobin and nitrates contents in blood in methemoglobinemia cases. The violuric acid and methylene blue protective mechanisms are in all probability influenced by the antioxidant properties of these substances and their reductase activity.

• Authors: A T Burbello, G A Baskovich, E G Dobrokhotova, V I Slesarev
• Journal: Gigiena truda i professional'nye zabolevaniia (Gig Tr Prof Zabol) Issue 8 Pg. 13-5 ( 1991) ISSN: 0016-9919 [Print] Russia (Federation)
• Vernacular Title: Zashchitnoe deĭstvie antioksidantov pri metgemoglobinemii, vyzvannoĭ nitritom natriia v éksperimente.
• PMID: 1794697 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Vitamin E
• Unithiol
• Ascorbic Acid

Topics

• Animals
• Antioxidants (administration & dosage)
• Ascorbic Acid (administration & dosage)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Male
• Methemoglobinemia (chemically induced, drug therapy)
• Rats
• Unithiol (administration & dosage)
• Vitamin E (administration & dosage)