HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The association of MYO9B gene in Italian patients with inflammatory bowel diseases.

AbstractBACKGROUND:
Variants of myosin IXB (MYO9B) gene, encoding for a motor protein implicated in epithelial permeability, have been recently associated with inflammatory bowel disease.
AIMS:
To investigate the contribution of three polymorphisms of MYO9B gene for predisposition to Crohn's disease and ulcerative colitis, their association with clinical phenotypes, particularly intestinal permeability, and possible interaction with the CARD15 gene.
METHODS:
549 Crohn's disease patients, 658 ulcerative colitis patients and 674 controls were genotyped for the rs962917, rs1545620 and rs2305764 single nucleotide polymorphisms.
RESULTS:
Highly significant genotypic association with Crohn's disease and ulcerative colitis was shown for all three single nucleotide polymorphisms, with odds ratio ranging from 1.5 to 1.7 (P-value: <0.01 to <0.002). A significant difference in allele frequencies was also observed in inflammatory bowel disease patients, with the single most significant association for rs1545620, detected in 47% of Crohn's disease, 47% of ulcerative colitis patients and 42% of controls (P < 0.005). No association with specific sub-phenotypes was found, with the exception of a trend towards an abnormal intestinal permeability (P = 0.043) in Crohn's disease carrying the rs1545620 risk allele.
CONCLUSIONS:
Our findings confirm the association between the MYO9B polymorphisms and susceptibility to both ulcerative colitis and Crohn's disease, with a weak influence on sub-phenotypic expression.
AuthorsA Latiano, O Palmieri, M R Valvano, R D'Incà, R Caprilli, S Cucchiara, G C Sturniolo, F Bossa, A Andriulli, V Annese
JournalAlimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 27 Issue 3 Pg. 241-8 (Feb 01 2008) ISSN: 1365-2036 [Electronic] England
PMID17944996 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • NOD2 protein, human
  • Nod2 Signaling Adaptor Protein
  • myosin IXB
  • Myosins
Topics
  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Colitis, Ulcerative (genetics, pathology)
  • Crohn Disease (genetics, pathology)
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Haplotypes
  • Humans
  • Infant
  • Inflammatory Bowel Diseases (genetics, pathology)
  • Intestinal Mucosa (pathology)
  • Italy
  • Linkage Disequilibrium
  • Male
  • Middle Aged
  • Myosins (genetics)
  • Nod2 Signaling Adaptor Protein (genetics)
  • Odds Ratio
  • Permeability
  • Phenotype
  • Polymorphism, Single Nucleotide

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: