HIV-associated Kaposi sarcoma: pathogenesis and therapy.

Abstract

While classical Kaposi sarcoma is a slowly progressing tumor, AIDS-related Kaposi sarcoma is much more aggressive. After introduction of antiretroviral therapy and with the use of well- tolerated chemotherapeutic agents, complete remission of the tumor can be achieved. Local therapeutic options include excision, cryosurgery, radiation and alitretinoin gel. In 45 % of patients with more than 400/microl CD4+ lymphocytes, interferon-alpha induces complete remission. New concepts of pathogenesis lead to therapeutic targets, such as inhibition of angiogenesis.

• Authors: Anja Potthoff, Norbert H Brockmeyer
• Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG (J Dtsch Dermatol Ges) Vol. 5 Issue 12 Pg. 1091-4 (Dec 2007) ISSN: 1610-0387 [Electronic] Germany
• PMID: 17944950 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anti-HIV Agents

Topics

• Acquired Immunodeficiency Syndrome (complications, diagnosis, therapy)
• Adult
• Anti-HIV Agents (therapeutic use)
• Combined Modality Therapy
• Diagnosis, Differential
• Herpesvirus 8, Human (pathogenicity)
• Humans
• Risk Factors
• Sarcoma, Kaposi (diagnosis, etiology, therapy)
• Skin Neoplasms (diagnosis, etiology, therapy)
• Virulence