Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury.
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| Abstract |
Once developed, end-stage renal disease cannot be reversed by any current therapy. Bone morphogenetic protein-7 (BMP-7), however, is a possible treatment for reversing end-stage renal disease. Previously, we showed that the BMP antagonist uterine sensitization-associated gene-1 (USAG-1, also known as ectodin and sclerostin domain-containing 1) negatively regulates the renoprotective action of BMP-7. Here, we show that the ratio between USAG-1 and BMP-7 expression increased dramatically in the later stage of kidney development, with USAG-1 expression overlapping BMP-7 only in differentiated distal tubules. Examination of USAG-1 expression in developing kidney indicated that a mosaic of proximal and distal tubule marker-positive cells reside side by side in the immature nephron. This suggests that each cell controls its own fate for becoming a proximal or distal tubule cell. In kidney injury models, the ratio of USAG-1 to BMP-7 expression decreased with kidney damage but increased after subsequent kidney regeneration. Our study suggests that USAG-1 expression in a kidney biopsy could be useful in predicting outcome.
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| Authors | M Tanaka, S Endo, T Okuda, A N Economides, D M Valenzuela, A J Murphy, E Robertson, T Sakurai, A Fukatsu, G D Yancopoulos, T Kita, M Yanagita |
| Journal | Kidney international (Kidney Int) Vol. 73 Issue 2 Pg. 181-91 (Jan 2008) ISSN: 0085-2538 [Print] United States |
| PMID | 17943079 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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