Abstract |
We have analysed the expression of the endogenous angiogenesis inhibitor endostatin/ collagen XVIII following stab wound injury and observed a highly significant (p<0.0001) lesional accumulation confined to areas of pan-necrotic injury and developing secondary damage. Maximal cell numbers were detected at Day 14, declining until Day 21 after injury. Further, endostatin/ collagen XVIII(+) monocytic cells accumulated in Virchow-Robin spaces where they formed cell clusters. Besides being prevailingly localised to ED1(+) activated microglia/macrophages, endostatin/ collagen XVIII expression was also detected by subendothelial surrounding vessels in the lesioned area. Late and prolonged accumulation of endostatin/ collagen XVIII(+) microglia/macrophages and increased numbers of endostatin/ collagen XVIII(+) subendothelial cells/vessels in areas of vascular pruning and regression, point to a role in the termination of the transient angiogenic response, linked to a "late" inflammatory milieu.
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Authors | C A Mueller, H J Schluesener, U Fauser, S Conrad, J M Schwab |
Journal | Experimental neurology
(Exp Neurol)
Vol. 208
Issue 2
Pg. 228-37
(Dec 2007)
ISSN: 0014-4886 [Print] United States |
PMID | 17942095
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiogenesis Inhibitors
- Collagen Type XVIII
- Endostatins
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Topics |
- Angiogenesis Inhibitors
(metabolism)
- Animals
- Blood Vessels
(physiopathology)
- Brain
(blood supply, metabolism, pathology)
- Brain Injuries
(metabolism, pathology, physiopathology)
- Collagen Type XVIII
(metabolism)
- Endostatins
(metabolism)
- Macrophages
(metabolism, pathology)
- Male
- Microglia
(metabolism, pathology)
- Necrosis
- Rats
- Rats, Sprague-Dawley
- Tissue Distribution
- Wounds, Stab
(metabolism, pathology, physiopathology)
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