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Lesional expression of the endogenous angiogenesis inhibitor endostatin/collagen XVIII following traumatic brain injury (TBI).

Abstract
We have analysed the expression of the endogenous angiogenesis inhibitor endostatin/collagen XVIII following stab wound injury and observed a highly significant (p<0.0001) lesional accumulation confined to areas of pan-necrotic injury and developing secondary damage. Maximal cell numbers were detected at Day 14, declining until Day 21 after injury. Further, endostatin/collagen XVIII(+) monocytic cells accumulated in Virchow-Robin spaces where they formed cell clusters. Besides being prevailingly localised to ED1(+) activated microglia/macrophages, endostatin/collagen XVIII expression was also detected by subendothelial surrounding vessels in the lesioned area. Late and prolonged accumulation of endostatin/collagen XVIII(+) microglia/macrophages and increased numbers of endostatin/collagen XVIII(+) subendothelial cells/vessels in areas of vascular pruning and regression, point to a role in the termination of the transient angiogenic response, linked to a "late" inflammatory milieu.
AuthorsC A Mueller, H J Schluesener, U Fauser, S Conrad, J M Schwab
JournalExperimental neurology (Exp Neurol) Vol. 208 Issue 2 Pg. 228-37 (Dec 2007) ISSN: 0014-4886 [Print] United States
PMID17942095 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Angiogenesis Inhibitors
  • Collagen Type XVIII
  • Endostatins
Topics
  • Angiogenesis Inhibitors (metabolism)
  • Animals
  • Blood Vessels (physiopathology)
  • Brain (blood supply, metabolism, pathology)
  • Brain Injuries (metabolism, pathology, physiopathology)
  • Collagen Type XVIII (metabolism)
  • Endostatins (metabolism)
  • Macrophages (metabolism, pathology)
  • Male
  • Microglia (metabolism, pathology)
  • Necrosis
  • Rats
  • Rats, Sprague-Dawley
  • Tissue Distribution
  • Wounds, Stab (metabolism, pathology, physiopathology)

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