Abstract | BACKGROUND: Subcutaneous immunoglobulin (SCIG) is an option for replacement therapy in patients with humoral immune deficiencies. OBJECTIVE: METHODS: An 11-year-old boy receiving monthly intravenous immunoglobulin ( IVIG) since 5 years of age presented to an academic medical center after moving to the area. The patient also had a history of von Willebrand disease. He had started receiving IVIG because of recurrent infections and an absent IgG subclass 3. Further immunologic assessment revealed a normal B-cell count, decreased IgM level, and an abnormal response to bacteriophage phiX174. Given these findings and the lack of another cause, the patient was diagnosed as having CVID. Because of difficult intravenous access, a port was placed for IVIG administration in 1999. The initial port was removed because of infectious complications, and a second port was found to be distally displaced in the right atrium, requiring removal. RESULTS: Continued difficulties with intravenous access and the potential complications with maintaining a long-term indwelling catheter prompted consideration of alternative methods for immunoglobulin administration. After removal of the port, the patient was prescribed weekly SCIG infusions. He tolerated the infusions well without bleeding complications related to the von Willebrand disease and was able to transition to home infusions. CONCLUSIONS:
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Authors | Rajiv Arora, Thomas C Newton, Michael R Nelson |
Journal | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
(Ann Allergy Asthma Immunol)
Vol. 99
Issue 4
Pg. 367-70
(Oct 2007)
ISSN: 1081-1206 [Print] United States |
PMID | 17941286
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Child
- Common Variable Immunodeficiency
(complications, diagnosis, therapy)
- Humans
- Immunization, Passive
(methods)
- Immunoglobulins
(administration & dosage, therapeutic use)
- Infusions, Parenteral
- Male
- Treatment Outcome
- von Willebrand Diseases
(complications)
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