HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Neuroprotective role of Bacopa monnieri extract in epilepsy and effect of glucose supplementation during hypoxia: glutamate receptor gene expression.

Abstract
The experiments were designed to study the glutamate gene expression during epilepsy in adult and hypoxic insult to brain during the neonatal period and the therapeutic role of neuroprotective supplements. We investigated the role of metabotropic glutamate-8 receptor (mGluR8) gene expression in cerebellum during epilepsy and neuroprotective role of Bacopa monnieri extract in epilepsy. We also studied the effect of NMDA receptor 1 (NMDAR1) gene expression during neonatal hypoxia and therapeutic role of glucose, oxygen and epinephrine supplementation. During epilepsy a significant down-regulation (P < 0.01) of mGluR8 gene expression was observed which was up-regulated (P < 0.05) near control level after B. monnieri treatment which is supported by Morris water maze experiment. In hypoxic neonates we observed up-regulation (P < 0.001) of the NMDAR1 gene expression whereas glucose and glucose + oxygen was able to significantly reverse (P < 0.001) the gene expression to near control level when compared to hypoxia and epinephrine treatment which was supported by open field test. Our results showed that B. monnieri treatment to epileptic rats significantly brought the reversal of the down-regulated mgluR8 gene expression toward control level. In neonatal rats, hypoxia induced expressional and functional changes in the NMDAR1 receptors of neuronal cells which is corrected by supplementation of glucose alone or glucose followed by oxygen during the resuscitation to prevent the glutamate related neuronal damage. Thus, the results suggest the clinical significance of corrective measures for epileptic and hypoxic management.
AuthorsC S Paulose, Finla Chathu, S Reas Khan, Amee Krishnakumar
JournalNeurochemical research (Neurochem Res) Vol. 33 Issue 9 Pg. 1663-71 (Sep 2008) ISSN: 1573-6903 [Electronic] United States
PMID17940877 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adrenergic Agonists
  • NMDA receptor A1
  • Neuroprotective Agents
  • Plant Extracts
  • Receptors, Glutamate
  • Receptors, Metabotropic Glutamate
  • Receptors, N-Methyl-D-Aspartate
  • metabotropic glutamate receptor 8
  • Glucose
  • Epinephrine
Topics
  • Adrenergic Agonists (pharmacology)
  • Adult
  • Animals
  • Animals, Newborn
  • Bacopa (chemistry)
  • Behavior, Animal (drug effects, physiology)
  • Brain (drug effects, pathology, physiology)
  • Epilepsy (drug therapy, pathology, physiopathology)
  • Epinephrine (pharmacology)
  • Gene Expression Regulation
  • Glucose (administration & dosage, pharmacology)
  • Humans
  • Hypoxia (pathology)
  • Male
  • Maze Learning (drug effects, physiology)
  • Neuroprotective Agents (chemistry, therapeutic use)
  • Phytotherapy
  • Plant Extracts (therapeutic use)
  • Rats
  • Rats, Wistar
  • Receptors, Glutamate (genetics, metabolism)
  • Receptors, Metabotropic Glutamate (genetics, metabolism)
  • Receptors, N-Methyl-D-Aspartate (genetics, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: