[Telomeric chromosome fusion in cells with micronuclei under the combined action of hyperthermia and hypothermia and halogenated analogs of thymidine].

Abstract

The reaction of cells with micronuclei in respect of the induction of specific dicentric chromosomes with halogenated analogs of thymidine at various temperatures was studied. The positive correlation between the temperature and frequency of dicentrics was shown for all halogenated analogs of thymidine. The minimum frequency of dicentrics was found in the case when used 5-iododeoxyuridine and hypothermia (34 degrees C). The using of 5-bromodeoxyuridine at different temperatures displayed the intermediate results. The maximum level of dicentrics discovered under action of 5-chlorodeoxyuridine and hyperthermia (40 degrees C). In the former case the depression of mitotic chromosome condensation of micronuclei registered, in the latter one the chromosomes with portions of delayed spiralization were not found.

• Authors: V I Stobetskiĭ
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 112 Issue 7 Pg. 72-3 (Jul 1991) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Telomernoe sliianie khromosom v kletkakh s mikroiadrami v usloviiakh sochetannogo vozdeĭstviia giper- ili gipotermii i galogenovykh analogov timidina.
• PMID: 1793864 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• 5-chloro-2'-deoxyuridine
• Bromodeoxyuridine
• Idoxuridine
• Thymidine
• Deoxyuridine

Topics

• Animals
• Bromodeoxyuridine (pharmacology)
• Cells, Cultured
• Chromosome Aberrations
• Cricetinae
• Cricetulus
• Deoxyuridine (analogs & derivatives, pharmacology)
• Idoxuridine (pharmacology)
• Micronuclei, Chromosome-Defective (drug effects)
• Telomere
• Temperature
• Thymidine (analogs & derivatives)