[Effects of a polypeptide drug on the state of energy metabolism of myocardial cells in hypoxic and ischemic conditions].

Abstract

Cordialin, the agent extracted from the heart, is known to inhibit hyperoxidation of succinic acid, increasing NADH oxidation speed in suspension of cardiomyocytes in hypoxia. Cordialin presence in oxygenated cells' suspension oxidating succinate, doesn't change oxygen consumption speed. The results received may be a theoretical basis for cordialin utilization in therapy of myocardial diseases, associated with hypoxia and ischemia. Cordialin utilization may be recommended for the treatment of acute myocardial infarction and for prolongation of time-period for thrombolytic therapy, treatment of IMD, angina and other pathological states, in which oxygen transport disturbance to myocardium cells occurs.

• Authors: V S Pavlenko, V I Ershov, L I Andreeva, S T Kazantseva, V Kh Khavinson
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 112 Issue 7 Pg. 24-7 (Jul 1991) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie polipeptidnogo preparata na sostoianie énergeticheskogo metabolizma kletok miokarda, nakhodiashchikhsia v usloviiakh gipoksii i ishemii.
• PMID: 1793841 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cardiovascular Agents
• Intercellular Signaling Peptides and Proteins
• Peptides
• Succinates
• NAD
• cordialin

Topics

• Animals
• Cardiovascular Agents (pharmacology)
• Coronary Disease (drug therapy, metabolism)
• Heart (drug effects)
• In Vitro Techniques
• Intercellular Signaling Peptides and Proteins
• Myocardial Infarction (drug therapy)
• Myocardium (cytology, metabolism)
• NAD (metabolism)
• Oxygen Consumption (drug effects)
• Peptides (pharmacology)
• Rats
• Succinates (metabolism)