Abstract |
The antitumor activity of the sea snake venom (Lapemis curtus) was evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different doses tested, 6.50 microg/ml at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 201.25%.
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Authors | R Karthikeyan, S Karthigayan, M Sri Balasubashini, S T Somasundaram, T Balasubramanian |
Journal | Toxicon : official journal of the International Society on Toxinology
(Toxicon)
Vol. 51
Issue 1
Pg. 157-61
(Jan 2008)
ISSN: 0041-0101 [Print] England |
PMID | 17936322
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Elapid Venoms
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Carcinoma, Ehrlich Tumor
(drug therapy, pathology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Elapid Venoms
(pharmacology)
- HeLa Cells
- Humans
- Mice
- Time Factors
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