Abstract | BACKGROUND: METHODS AND RESULTS: Physiologically controlled male Sprague-Dawley rats were anesthetized with isoflurane, paralyzed with pancuronium and mechanically ventilated. A guide wire was introduced via the femoral artery and advanced retrogradely via the aorta into the left coronary artery under fluoroscopic guidance. Rats with established coronary ischemia (85 min after occlusion) were given STAZN 3.5 mg/kg or its vehicle 5 min before and 2 h after reperfusion, and were subjected to functional and histopathologic studies at 3 days. Ischemia-associated Q wave amplitude was reduced by 73% in STAZN-treated rats (P=0.01), while infarct-related ejection fraction, fractional shortening and severe regional wall-motion impairments were improved by 48%, 54% and 37%, respectively, relative to vehicle-treated controls (P=0.05). Total myocardial infarct volume in STAZN-treated rats was correspondingly reduced by 43% (P<0.05), representing a sparing of 14% of the total left ventricular myocardium. CONCLUSIONS:
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Authors | James J Ley, Ricardo Prado, Jian Qin Wei, Nanette H Bishopric, David A Becker, Myron D Ginsberg |
Journal | Biochemical pharmacology
(Biochem Pharmacol)
Vol. 75
Issue 2
Pg. 448-56
(Jan 15 2008)
ISSN: 0006-2952 [Print] England |
PMID | 17936251
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Neuroprotective Agents
- Sesquiterpenes
- stilbazulenyl nitrone
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Topics |
- Animals
- Antioxidants
(therapeutic use)
- Electrocardiography
(drug effects)
- Male
- Myocardial Ischemia
(drug therapy)
- Myocardial Reperfusion Injury
(prevention & control)
- Myocardium
(pathology)
- Neuroprotective Agents
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Sesquiterpenes
(pharmacology, therapeutic use)
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