Abstract | BACKGROUND: METHODS: This was a cross-sectional study of 3 groups of women matched for age and body mass index: group 1, overweight controls (n = 13); group 2, BND (n = 10); and group 3, RYGB (n = 13). Venous blood was drawn with the patient in the fasted state and throughout a 3-hour period after a liquid meal. RESULTS: The fasting glucose level was similar between the 2 surgery groups; however, the fasting insulin concentrations were greater in the BND (10.0 microU/mL) than in the RYGB (6.2 microU/mL; P <0.05) group. The glucose level at 60 minutes was significantly lower in the RYGB group (70 mg/dL, range 38-82) than in the BND group (83 mg/dL, range 63-98). The GLP-1 levels at 30 minutes were more than threefold greater in the RYGB group (96 pmol/L) compared with the BND and overweight control (28 pmol/L) groups. The GLP-1 and insulin concentrations correlated at 30 minutes only in the RYGB group (r = .66; P = .013). The glucose-dependent insulinotropic peptide levels at 30 minutes were lower in the RYGB group (20 pmol/L) than in the BND group (31 pmol/L) or overweight control group (33 pmol/L). The peak glucagon levels were similar among the 3 groups. CONCLUSION:
|
Authors | Judith Korner, Marc Bessler, William Inabnet, Carmen Taveras, Jens Juul Holst |
Journal | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
(Surg Obes Relat Dis)
2007 Nov-Dec
Vol. 3
Issue 6
Pg. 597-601
ISSN: 1550-7289 [Print] United States |
PMID | 17936091
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Gastric Inhibitory Polypeptide
- Glucagon-Like Peptide 1
- Glucagon
|
Topics |
- Adult
- Analysis of Variance
- Cross-Sectional Studies
- Female
- Gastric Bypass
- Gastric Inhibitory Polypeptide
(metabolism)
- Gastroplasty
- Glucagon
(metabolism)
- Glucagon-Like Peptide 1
(metabolism)
- Humans
- Middle Aged
- Obesity, Morbid
(metabolism, surgery)
- Postprandial Period
|