Abstract | PURPOSE: Herein we report that carboplatin infusion influenced tumor blood flow signal independent of the mechanical decompression induced by the artificial lymphatics system technology that was being evaluated as part of a randomized veterinary clinical trial, treating spontaneously occurring canine appendicular osteosarcoma, a tumor very similar to its human counterpart. METHODS: Blood flow within the central region of the tumor was recorded continuously using laser Doppler flowmetry, a real-time measurement technology. Time-averaged flow values were computed from segments taken from the recordings immediately before starting carboplatin infusion, and during infusion. RESULTS:
Carboplatin increased the tumor blood flow signal by an additional 59 +/- 26% (mean +/- SEM; p = 0.06) over the increase induced by the decompression. The increase started within 49 +/- 46 s after the start of infusion, had a response time constant of 19 +/- 21 s and persisted throughout the infusion, ending shortly after infusion ended. CONCLUSION: The rapidity of the flow signal increase suggests that carboplatin may have an autonomic effect on circulation, either local or systemic. The observations identify a new action of this drug and suggest a possible mechanism to exploit therapeutically.
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Authors | Gene R DiResta, Sean W Aiken, Holly K Brown, Philip J Bergman, Ann Hohenhaus, John H Healey |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 62
Issue 3
Pg. 545-9
(Aug 2008)
ISSN: 0344-5704 [Print] Germany |
PMID | 17932675
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Carboplatin
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Bone Neoplasms
(blood supply, drug therapy, veterinary)
- Carboplatin
(administration & dosage, therapeutic use)
- Dog Diseases
(drug therapy)
- Dogs
- Drug Delivery Systems
- Electrocardiography
- Infusions, Intravenous
- Laser-Doppler Flowmetry
- Microcirculation
(drug effects)
- Osteosarcoma
(blood supply, drug therapy, veterinary)
- Time Factors
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