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Influence of carboplatin infusion on osteosarcoma blood flow.

AbstractPURPOSE:
Herein we report that carboplatin infusion influenced tumor blood flow signal independent of the mechanical decompression induced by the artificial lymphatics system technology that was being evaluated as part of a randomized veterinary clinical trial, treating spontaneously occurring canine appendicular osteosarcoma, a tumor very similar to its human counterpart.
METHODS:
Blood flow within the central region of the tumor was recorded continuously using laser Doppler flowmetry, a real-time measurement technology. Time-averaged flow values were computed from segments taken from the recordings immediately before starting carboplatin infusion, and during infusion.
RESULTS:
Carboplatin increased the tumor blood flow signal by an additional 59 +/- 26% (mean +/- SEM; p = 0.06) over the increase induced by the decompression. The increase started within 49 +/- 46 s after the start of infusion, had a response time constant of 19 +/- 21 s and persisted throughout the infusion, ending shortly after infusion ended.
CONCLUSION:
The rapidity of the flow signal increase suggests that carboplatin may have an autonomic effect on circulation, either local or systemic. The observations identify a new action of this drug and suggest a possible mechanism to exploit therapeutically.
AuthorsGene R DiResta, Sean W Aiken, Holly K Brown, Philip J Bergman, Ann Hohenhaus, John H Healey
JournalCancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 62 Issue 3 Pg. 545-9 (Aug 2008) ISSN: 0344-5704 [Print] Germany
PMID17932675 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Carboplatin
Topics
  • Animals
  • Antineoplastic Agents (administration & dosage, therapeutic use)
  • Bone Neoplasms (blood supply, drug therapy, veterinary)
  • Carboplatin (administration & dosage, therapeutic use)
  • Dog Diseases (drug therapy)
  • Dogs
  • Drug Delivery Systems
  • Electrocardiography
  • Infusions, Intravenous
  • Laser-Doppler Flowmetry
  • Microcirculation (drug effects)
  • Osteosarcoma (blood supply, drug therapy, veterinary)
  • Time Factors

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