Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men.

Abstract

OBJECTIVE:

In culture studies matrix metalloproteinase (MMP)-8 thins the protecting fibrous cap of the atherosclerotic plaque thereby increasing its vulnerability. Results on the association of serum MMP-8 concentrations and cardiovascular diseases (CVD) are, however, scarce and contradictory.

METHODS AND RESULTS:

We analyzed the association between CVD or subclinical atherosclerosis and serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations of 1018 men with the follow-up time of 10 years. MMP-8 concentrations or MMP-8/TIMP-1 ratios were higher in men with prevalent CVD or subclinical atherosclerosis at baseline than those without. In men free of CVD at baseline, MMP-8 concentrations associated with acute myocardial infarction, death from coronary heart disease (CHD), CVD, or from any cause with relative risks (RR) (95% CI) of 1.138 (1.009 to 1.284), 1.188 (1.034 to 1.365), 1.171 (1.026 to 1.338), and 1.136 (1.018 to 1.269), respectively, and MMP-8/TIMP-1 ratio with CHD death with an RR of 1.206 (1.028 to 1.414) per standard deviation (SD) increase. In men with no prevalent CVD but with subclinical atherosclerosis at baseline, elevated serum MMP-8 concentration predicted CVD death with an RR of 3.03 (1.09 to 8.44). TIMP-1 concentrations alone had no predictive value.

CONCLUSIONS:

The results indicate that serum MMP-8 concentrations are elevated in prevalent or subclinical atherosclerosis and associate with the worst cardiovascular outcome.

• Authors: Anita M Tuomainen, Kristiina Nyyssönen, Jari A Laukkanen, Taina Tervahartiala, Tomi-Pekka Tuomainen, Jukka T Salonen, Timo Sorsa, Pirkko J Pussinen
• Journal: Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol) Vol. 27 Issue 12 Pg. 2722-8 (Dec 2007) ISSN: 1524-4636 [Electronic] United States
• PMID: 17932311 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Tissue Inhibitor of Metalloproteinase-1
• Matrix Metalloproteinase 8

Topics

• Atherosclerosis (blood, complications, mortality)
• Biomarkers (blood)
• Cardiovascular Diseases (blood, etiology, mortality)
• Coronary Disease (blood, etiology)
• Finland (epidemiology)
• Follow-Up Studies
• Humans
• Linear Models
• Male
• Matrix Metalloproteinase 8 (blood)
• Middle Aged
• Myocardial Infarction (blood, etiology)
• Prevalence
• Prognosis
• Proportional Hazards Models
• Prospective Studies
• ROC Curve
• Risk Assessment
• Risk Factors
• Survival Analysis
• Time Factors
• Tissue Inhibitor of Metalloproteinase-1 (blood)