Abstract | UNLABELLED: CASE REPORT: A 4-month-old boy was admitted for anorexia, weakness, hypotonia, constipation and lethargy. Initial physical examination evidenced a severe axial hypotonia, signs of moderate intracellular dehydration, polyuria and leucocyturia. Hemodynamic parameters were normal. The infant's origin was Turkish. Basic blood chemistry showed a high serum calcium concentration of 4.28 and 4.55 mmol/l on a second control. The EKG showed a short QTc interval calculated at 0.34 s. Due to worsening neurological condition, the infant was referred to the pediatric intensive care unit. Because of the association of neurological impairment, EKG abnormality and high serum calcium level, haemodialysis was performed. Treatment included hyperhydration, high doses of intravenous of loop diuretics and sodium pamidronate infusion. Hormonal, radiological, abdominal and cardiac investigations combined with a new parental interview led to the diagnosis of vitamin D intoxication due to excessive daily administration. We were unable to determine the exact total amount because of the language barrier. Clinical outcome was marked by nephrocalcinosis without renal function impairment, iliac venous thrombosis secondary to the dialysis catheter and a full neurological recovery without sequelae after 3 months. DISCUSSION:
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Authors | C Chambellan-Tison, B Horen, G Plat-Wilson, P Moulin, I Claudet |
Journal | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
(Arch Pediatr)
Vol. 14
Issue 11
Pg. 1328-32
(Nov 2007)
ISSN: 0929-693X [Print] France |
Vernacular Title | Hypercalcémie majeure secondaire à une intoxication par la vitamine D. |
PMID | 17931839
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
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Topics |
- Child, Preschool
- France
- Humans
- Hypercalcemia
(chemically induced)
- Male
- Poisoning
(complications)
- Severity of Illness Index
- Turkey
(ethnology)
- Vitamin D
(poisoning)
- Vitamins
(poisoning)
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