Abstract |
A 9-month-old boy with known familial neurofibromatosis type I (NF-1) presented with a clinical and laboratory picture suggestive of juvenile chronic myelomonocytic leukemia (JCMMoL). Chromosomal studies obtained from the bone marrow indicated, however, that he had monosomy 7 syndrome. We believe this is the first reported case of monosomy 7 syndrome in a child with NF in the United States, and that this case complements a recent report of two cases of NF, JCMMoL, and monosomy 7 in Japanese children. Since monosomy 7 syndrome is very difficult to differentiate from JCMMoL or acute nonlymphocytic leukemia (ANLL) unless appropriate chromosomal studies are obtained, we believe it is possible that monosomy 7 may occur with increased frequency in patients with NF-1. Monosomy 7 syndrome might therefore be a significant cause of the known association between NF-1 and nonlymphoid leukemia.
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Authors | J F Kelleher, T V Carbone |
Journal | The American journal of pediatric hematology/oncology
(Am J Pediatr Hematol Oncol)
Vol. 13
Issue 3
Pg. 338-41
( 1991)
ISSN: 0192-8562 [Print] United States |
PMID | 1793161
(Publication Type: Case Reports, Journal Article, Review)
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Chemical References |
- Cytarabine
- Etoposide
- Dexamethasone
- Thioguanine
- Daunorubicin
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bone Marrow Transplantation
- Chromosomes, Human, Pair 7
- Combined Modality Therapy
- Cytarabine
(administration & dosage)
- Daunorubicin
(administration & dosage)
- Dexamethasone
(administration & dosage)
- Diagnosis, Differential
- Etoposide
(administration & dosage)
- Humans
- Infant
- Leukemia, Myelomonocytic, Chronic
(diagnosis)
- Male
- Monocytes
(pathology)
- Monosomy
- Neurofibromatosis 1
(complications, genetics)
- Pedigree
- Preleukemia
(complications, diagnosis, drug therapy, genetics, surgery)
- Syndrome
- Thioguanine
(administration & dosage)
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