A pragmatic randomized controlled trial on the effectiveness of highly concentrated saline spa water baths followed by UVB compared to UVB only in moderate to severe psoriasis.

There is a lack of sufficiently large randomized trials evaluating the effectiveness of saline spa balneophototherapy compared to ultraviolet B (UVB) only.
The study aimed to evaluate whether highly concentrated saline spa water baths followed by UVB (HC-SSW-UVB) are superior to UVB only in moderate to severe psoriasis.
One hundred and sixty (160) adults with a Psoriasis Area and Severity Index (PASI) of >10 from 4 German spa centers were randomly allocated to HC-SSW-UVB (local sodium chloride concentration between 25% and 27%) or UVB only 3 a week until remission (PASI < 5) or for a maximum of 6 weeks. Reduction of PASI > or = 50% (PASI-50) at the end of the intervention period was defined as primary outcome. Only persons receiving at least 1 intervention were included into the primary analysis.
Participants allocated to HC-SSW-UVB attained to a statistically significantly higher rate of PASI-50 than patients allocated to UVB only (68/79 [86%] versus 38/71 [54%]; p < 0.001; number needed to treat, 3.1; 95% confidence interval, 2.1-6.0). Postintervention analysis did not yield a clear hint of a persisting effect.
The study indicates that HC-SSW-UVB are superior to routine UVB at the end of a 6-week treatment course.
AuthorsThomas Brockow, Ralf Schiener, Annegret Franke, Karl Ludwig Resch, Ralf Uwe Peter
JournalJournal of alternative and complementary medicine (New York, N.Y.) (J Altern Complement Med) Vol. 13 Issue 7 Pg. 725-32 (Sep 2007) ISSN: 1075-5535 [Print] United States
PMID17931065 (Publication Type: Controlled Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Sodium Chloride
  • Adult
  • Balneology (methods)
  • Combined Modality Therapy
  • Female
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Psoriasis (therapy)
  • Severity of Illness Index
  • Sodium Chloride (administration & dosage)
  • Treatment Outcome
  • Ultraviolet Therapy (methods)

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