15-Deoxyspergualin (15-DOS) has a curative effect on the development of SLE-like autoimmune disease in MRL/1 mice.

Abstract

Treating MRL/1pr mice, which spontaneously develop systemic lupus erythematosus and rheumatoid arthritis, with 15-DOS resulted in a decrease in the amount of autoantibodies and inhibited proteinuria of the developing glomerulonephritis with an improved survival rate of these autoimmune mice. 15-DOS treatment also lowered the percentage of animals with swollen lymph nodes and inhibited the development of splenomegaly. In the established disease 15-DOS returned urine-protein values and renal function (serum urea and creatinine) to normal levels. Circulating rheumatoid factor and autoantibodies to double-stranded DNA were reduced and the increase in paw volume (signs of a polyarthritis) was inhibited.

• Authors: H U Schorlemmer, R R Bartlett, F R Seiler
• Journal: Agents and actions (Agents Actions) Vol. 34 Issue 1-2 Pg. 151-5 (Sep 1991) ISSN: 0065-4299 [Print] Switzerland
• PMID: 1793021 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Guanidines
• Immunosuppressive Agents
• Rheumatoid Factor
• gusperimus

Topics

• Animals
• Arthritis, Rheumatoid (drug therapy)
• Autoantibodies (analysis)
• Autoimmune Diseases (drug therapy)
• Female
• Glomerulonephritis (drug therapy, prevention & control)
• Guanidines (therapeutic use)
• Immunosuppressive Agents (therapeutic use)
• Injections, Intraperitoneal
• Lupus Erythematosus, Systemic (drug therapy)
• Male
• Mice
• Mice, Inbred Strains
• Rheumatoid Factor (analysis)