[The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions].

Abstract

Toxic hepatitis developed but in one out of 127 peptic ulcer patients treated with cimetidine. In patients (n-142) treated with gastrozepine, no cases of toxic hepatitis were recorded. These anti-ulcer agents did not influence absorptive capacities of the liver or hepatic blood flow. Meanwhile microsomal exidase (antitoxic) function of hepatocytes noticeably declined as a result of cimetidine treatment in every 8th patient with peptic ulcer subjected to the continuous 5-week treatment with the drug and in every 5th patient given the treatment (maintenance included) for a longer time. In patients suffering from liver cirrhosis with secondary gastroduodenal ulcers or multiple erosions, the 5-week treatment either with almagel and platyphylline or gastrozepine provided approximately similar results and promoted ulcer and erosion healing in half the cases. Adjuvant 3-week therapy with sucralfate (venter) having cytoprotective properties led to the disappearance of gastroduodenal ulcers and erosions in 23 out of 26 patients, in whom the previous treatment was ineffective.

• Authors: L I Geller, G A Bessonova, M V Griaznova
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 63 Issue 8 Pg. 78-81 ( 1991) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Vliianie tsimetidina i gastrotsepina na sostoianie pecheni i farmakoterapiia "gepatogennykh" gastroduodenal'nykh iazv i éroziĭ.
• PMID: 1792625 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Anti-Ulcer Agents
• Pirenzepine
• Cimetidine

Topics

• Adult
• Anti-Ulcer Agents (therapeutic use)
• Chemical and Drug Induced Liver Injury (etiology)
• Cimetidine (administration & dosage, adverse effects)
• Drug Evaluation
• Drug Therapy, Combination
• Humans
• Liver (drug effects, physiopathology)
• Liver Cirrhosis (complications)
• Male
• Middle Aged
• Peptic Ulcer (drug therapy, etiology, physiopathology)
• Pirenzepine (administration & dosage, adverse effects)
• Time Factors