Abstract | AIMS: METHODS: RESULTS: No effect of the polymorphism on diabetic neuropathy or diabetic nephropathy was found, but heterozygous or homozygous patients for the M55V polymorphism in the SUMO4 gene had a markedly reduced prevalence of diabetic retinopathy (odds ratio 0.37, 95%-confidence interval (CI) [0.32;0.43]; p=0.004). Furthermore, a multiple logistic regression model showed an age and diabetes duration independent effect of the M55V polymorphisms on the prevalence of diabetic retinopathy (p=0.03), but not of diabetic neuropathy or nephropathy. CONCLUSIONS:
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Authors | G Rudofsky Jr, A Schlotterer, P M Humpert, J Tafel, M Morcos, P P Nawroth, A Bierhaus, A Hamann |
Journal | Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
(Exp Clin Endocrinol Diabetes)
Vol. 116
Issue 1
Pg. 14-7
(Jan 2008)
ISSN: 0947-7349 [Print] Germany |
PMID | 17926234
(Publication Type: Journal Article)
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Chemical References |
- SUMO4 protein, human
- Small Ubiquitin-Related Modifier Proteins
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Topics |
- Adult
- Cross-Sectional Studies
- Diabetes Mellitus, Type 1
(complications, genetics)
- Diabetic Nephropathies
(genetics)
- Diabetic Neuropathies
(genetics)
- Diabetic Retinopathy
(epidemiology, genetics)
- Female
- Genotype
- Humans
- Logistic Models
- Male
- Middle Aged
- Odds Ratio
- Polymorphism, Genetic
- Small Ubiquitin-Related Modifier Proteins
(genetics)
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