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A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes.

AbstractAIMS:
We studied the association between a functionally relevant M55V polymorphism in the SUMO4 gene with microvascular diabetic complications in patients with type 1 diabetes.
METHODS:
223 patients with type 1 diabetes were studied using polymerase chain reaction and subsequent cleavage by restriction endonucleases for the M55V SUMO4 gene variant.
RESULTS:
No effect of the polymorphism on diabetic neuropathy or diabetic nephropathy was found, but heterozygous or homozygous patients for the M55V polymorphism in the SUMO4 gene had a markedly reduced prevalence of diabetic retinopathy (odds ratio 0.37, 95%-confidence interval (CI) [0.32;0.43]; p=0.004). Furthermore, a multiple logistic regression model showed an age and diabetes duration independent effect of the M55V polymorphisms on the prevalence of diabetic retinopathy (p=0.03), but not of diabetic neuropathy or nephropathy.
CONCLUSIONS:
Our data indicate that the M55V polymorphism in the SUMO4 gene is associated with a reduced risk of diabetic retinopathy in type 1 diabetes. Thus, the results of our study suggest that posttranslational modification of proteins via SUMO4 could contribute to the development of certain diabetic complications.
AuthorsG Rudofsky Jr, A Schlotterer, P M Humpert, J Tafel, M Morcos, P P Nawroth, A Bierhaus, A Hamann
JournalExperimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (Exp Clin Endocrinol Diabetes) Vol. 116 Issue 1 Pg. 14-7 (Jan 2008) ISSN: 0947-7349 [Print] Germany
PMID17926234 (Publication Type: Journal Article)
Chemical References
  • SUMO4 protein, human
  • Small Ubiquitin-Related Modifier Proteins
Topics
  • Adult
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 1 (complications, genetics)
  • Diabetic Nephropathies (genetics)
  • Diabetic Neuropathies (genetics)
  • Diabetic Retinopathy (epidemiology, genetics)
  • Female
  • Genotype
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Genetic
  • Small Ubiquitin-Related Modifier Proteins (genetics)

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