Abstract | BACKGROUND: METHODS: In 30 patients with chronic ischemia, bone marrow was aspirated from the iliac crest. During mononuclear cell isolation, coronary angiography was performed. Thereafter, 94+/-18 x 10(6) cells were injected intramyocardially (NOGA system) in regions with ischemia on technetium-99m tetrofosmin SPECT. RESULTS: During the 12-month follow-up period, there was no clinical evidence of progression of atherosclerosis. CCS class improved from 3.4+/-0.5 to 2.4+/-0.8 at 3 months, 2.4+/-0.9 at 6 months and 2.5+/-0.9 at 12 months (P<0.01). MRI-determined left ventricular ejection fraction increased from 51+/-12% to 54+/-12% at 3 months (P<0.01) and the number of ischemic segments per patient on SPECT decreased from 5.2+/-2.6 to 2.1+/-2.2 at 3 months (P<0.01). Repeat coronary angiography at 4 months revealed that bone marrow cell transplantation did not decrease minimal luminal diameter (1.81+/-0.80 mm versus 1.79+/-0.82 mm, P = NS) or mean luminal diameter (2.48+/-0.85 mm versus 2.46+/-0.86 mm, P = NS). Similarly, the percentage diameter stenosis (32+/-19% versus 32+/-20%, P = NS) and the atheromatosis severity score (4.78+/-2.40 versus 4.80+/-2.40, P = NS) remained unchanged. CONCLUSION:
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Authors | Saskia L M A Beeres, Jeroen J Bax, Stijntje D Roes, Hildo J Lamb, Willem E Fibbe, Albert De Roos, Ernst E Van Der Wall, Martin J Schalij, Douwe E Atsma |
Journal | Acute cardiac care
(Acute Card Care)
Vol. 9
Issue 4
Pg. 243-51
( 2007)
ISSN: 1748-2941 [Print] England |
PMID | 17926149
(Publication Type: Clinical Trial, Journal Article)
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Topics |
- Aged
- Bone Marrow Transplantation
- Coronary Angiography
- Coronary Artery Disease
(diagnosis, physiopathology, surgery)
- Female
- Humans
- Male
- Middle Aged
- Myocardial Ischemia
(surgery)
- Tomography, Emission-Computed, Single-Photon
- Transplantation, Autologous
- Treatment Outcome
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