Generally recognized as safe (GRAS) evaluation of 4-hexylresorcinol for use as a processing aid for prevention of melanosis in shrimp.

Abstract

4-Hexylresorcinol (C12H18O2) is proposed for use as a processing aid for prevention of melanosis ("black spot") in shrimp and as an alternative to the currently approved sulfites. A safety evaluation was conducted to affirm, based upon scientific procedures, the generally recognized as safe ("GRAS") status of 4-hexylresorcinol for proposed use. The GRAS safety evaluation compiled, reviewed, and analyzed data on the following areas: chemical identity, analytical methodology, historical and proposed uses, functionality, and safety. The publicly available safety data on 4-hexylresorcinol cover a broad range of potential toxicity concerns including acute and subacute toxicity, subchronic toxicity, carcinogenicity, mutagenicity, and allergenicity. These studies, along with the aforementioned data, demonstrate that 4-hexylresorcinol presents no risk of toxicity at the levels proposed for treatment of shrimp, and the use of 4-hexylresorcinol as a processing aid to prevent melanosis in shrimp is GRAS.

• Authors: V H Frankos, D F Schmitt, L C Haws, A J McEvily, R Iyengar, S A Miller, I C Munro, F M Clydesdale, A L Forbes, R M Sauer
• Journal: Regulatory toxicology and pharmacology : RTP (Regul Toxicol Pharmacol) Vol. 14 Issue 2 Pg. 202-12 (Oct 1991) ISSN: 0273-2300 [Print] Netherlands
• PMID: 1792354 (Publication Type: Journal Article)

Chemical References

• Hexylresorcinol

Topics

• Animals
• Decapoda
• Guinea Pigs
• Hexylresorcinol (toxicity)
• Humans
• Melanosis (prevention & control, veterinary)
• Mice
• Rats