Abstract | PURPOSE: To discuss the treatment and outcomes of inverted papilloma of the nasal cavity and paranasal sinuses. METHODS: Review of the pertinent literature. RESULTS:
Inverted papilloma is a benign, locally aggressive neoplasm that arises in the nasal cavity and is associated with squamous cell carcinoma in approximately 5% of patients. Squamous cell carcinoma may be present with inverted papilloma at the initial diagnosis or it may occur metachronously after prior treatment. Surgery is the primary treatment of inverted papilloma. The likelihood of local recurrence varies from less than 5% to over 50%, depending on the extent of resection. There is likely no significant difference in the risk of local recurrence after open compared with endoscopic resection. The probability of local recurrence and/or death from tumor is increased if inverted papilloma is associated with squamous cell carcinoma. The likelihood of cure is approximately 50% when malignancy is present and postoperative radiotherapy should be considered for the majority of patients. A small subset of patients with inverted papilloma present with incompletely resectable disease. Definitive radiotherapy using doses between 65 and 70 Gy will locally control gross disease in the majority of patients. CONCLUSION:
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Authors | William M Mendenhall, Russell W Hinerman, Robert S Malyapa, John W Werning, Robert J Amdur, Douglas B Villaret, Nancy P Mendenhall |
Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 30
Issue 5
Pg. 560-3
(Oct 2007)
ISSN: 1537-453X [Electronic] United States |
PMID | 17921720
(Publication Type: Journal Article, Review)
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Nose Neoplasms
(pathology, surgery)
- Papilloma
(pathology, surgery)
- Paranasal Sinus Neoplasms
(pathology, surgery)
- Treatment Outcome
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