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Tyk2 expression and its signaling enhances the invasiveness of prostate cancer cells.

Abstract
Protein tyrosine kinase plays a central role in the proliferation and differentiation of various types of cells. One of these protein kinases, Tyk2, a member of the Jak family kinases, is known to play important roles in receptor signal transduction by interferons, interleukins, growth factors, and other hormones. In the present study, we investigated Tyk2 expression and its role in the growth and invasiveness of human prostate cancer cells. We used a small interfering RNA targeting Tyk2 and an inhibitor of Tyk2, tyrphostin A1, to suppress the expression and signaling of Tyk2 in prostate cancer cells. We detected mRNAs for Jak family kinases in prostate cancer cell lines by RT-PCR and Tyk2 protein in human prostate cancer specimens by immunohistochemistry. Inhibition of Tyk2 signaling resulted in attenuation of the urokinase-type plasminogen activator-enhanced invasiveness of prostate cancer cells in vitro without affecting the cellular growth rate. These results suggest that Tyk2 signaling in prostate cancer cells facilitate invasion of these cells, and interference with this signaling may be a potential therapeutic pathway.
AuthorsHisamitsu Ide, Takashi Nakagawa, Yuichi Terado, Yutaka Kamiyama, Satoru Muto, Shigeo Horie
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 369 Issue 2 Pg. 292-6 (May 02 2008) ISSN: 1090-2104 [Electronic] United States
PMID17920038 (Publication Type: Journal Article)
Chemical References
  • TYK2 Kinase
  • TYK2 protein, human
Topics
  • Cell Line
  • Cell Proliferation
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Neoplasm Invasiveness
  • Prostatic Neoplasms (metabolism, pathology)
  • Signal Transduction
  • TYK2 Kinase (metabolism)

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