Prediction of genetic risk for dyslipidemia.

Abstract

The purpose of the present study was to identify genetic variants that confer susceptibility to dyslipidemia. A total of 5213 individuals from two independent populations were examined: Subject panel A comprised 3794 individuals who visited participating hospitals; subject panel B comprised 1419 community-dwelling elderly individuals. The genotypes for 100 polymorphisms of 65 candidate genes were determined. The chi(2) test and multivariable logistic regression analysis revealed that seven polymorphisms of APOA5, APOC3, APOA1, ACAT2, and LPL were significantly associated with hypertriglyceridemia, six polymorphisms of APOA5, LIPC, and CYP3A4 with low HDL-cholesterol, and three polymorphisms of APOE and CCR2 with high LDL-cholesterol in subject panel A. For validation of these associations, the same polymorphisms were examined in subject panel B. Six polymorphisms of APOA5, APOC3, APOA1, and LPL were again significantly associated with hypertriglyceridemia, three polymorphisms of APOA5 with low HDL-cholesterol, and two polymorphisms of APOE with high LDL-cholesterol. Serum triglyceride, HDL-cholesterol, and LDL-cholesterol concentrations differed significantly among genotypes of these corresponding polymorphisms in both subject panels. These results indicate that polymorphisms of APOA5, APOC3, APOA1, and LPL are determinants of hypertriglyceridemia and that those of APOA5 and APOE are determinants of low HDL-cholesterol and high LDL-cholesterol, respectively, in Japanese individuals.

• Authors: Yoshiji Yamada, Hitoshi Matsuo, Shunichiro Warita, Sachiro Watanabe, Kimihiko Kato, Mitsutoshi Oguri, Kiyoshi Yokoi, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Sahoko Ichihara, Yukitoshi Aoyagi, Akitomo Yasunaga, Hyuntae Park, Masashi Tanaka, Yoshinori Nozawa
• Journal: Genomics (Genomics) Vol. 90 Issue 5 Pg. 551-8 (Nov 2007) ISSN: 0888-7543 [Print] United States
• PMID: 17919884 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Apolipoproteins
• Biomarkers
• Cholesterol, HDL
• Cholesterol, LDL
• Lipids
• Lipoprotein Lipase

Topics

• Aged
• Apolipoproteins (genetics)
• Biomarkers
• Cholesterol, HDL (genetics)
• Cholesterol, LDL (genetics)
• Cohort Studies
• Dyslipidemias (genetics)
• Female
• Genotype
• Humans
• Lipids (blood)
• Lipoprotein Lipase (genetics)
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Prognosis
• Prospective Studies
• Risk Factors