Abstract |
In this study, we examined the effect of N-trans- feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.
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Authors | Mai Efdi, Kenji Ohguchi, Yukihiro Akao, Yoshinori Nozawa, Mamoru Koketsu, Hideharu Ishihara |
Journal | Biological & pharmaceutical bulletin
(Biol Pharm Bull)
Vol. 30
Issue 10
Pg. 1972-4
(Oct 2007)
ISSN: 0918-6158 [Print] Japan |
PMID | 17917275
(Publication Type: Journal Article)
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Chemical References |
- Coumaric Acids
- Melanins
- Plant Extracts
- feruloyltyramine
- Monophenol Monooxygenase
- Tyramine
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Topics |
- Animals
- Annonaceae
(chemistry)
- Blotting, Western
- Cell Line, Tumor
- Chromatography, High Pressure Liquid
- Coumaric Acids
(isolation & purification, pharmacology)
- Magnetic Resonance Spectroscopy
- Mass Spectrometry
- Melanins
(antagonists & inhibitors, biosynthesis)
- Melanoma, Experimental
(drug therapy, enzymology, pathology)
- Mice
- Monophenol Monooxygenase
(metabolism)
- Plant Extracts
(chemistry)
- Signal Transduction
(drug effects)
- Spectrophotometry, Infrared
- Tyramine
(analogs & derivatives, isolation & purification, pharmacology)
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