Abstract | BACKGROUND AND PURPOSE:
Carnosine is a naturally occurring dipeptide with multiple neuroprotective properties. In addition, it is well tolerated in high doses with minimal side effects. The purposes of this study were to determine whether carnosine is neuroprotective in permanent focal cerebral ischemia and to determine potential mechanisms of neuroprotection. METHODS: RESULTS: CONCLUSIONS:
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Authors | G K Rajanikant, Daniel Zemke, Marie-Claude Senut, Mark B Frenkel, Alex F Chen, Rishi Gupta, Arshad Majid |
Journal | Stroke
(Stroke)
Vol. 38
Issue 11
Pg. 3023-31
(Nov 2007)
ISSN: 1524-4628 [Electronic] United States |
PMID | 17916766
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Free Radical Scavengers
- Matrix Metalloproteinase Inhibitors
- Neuroprotective Agents
- Reactive Oxygen Species
- Carnosine
- Matrix Metalloproteinases
- Glutathione
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Topics |
- Animals
- Antioxidants
(pharmacology, therapeutic use)
- Brain
(drug effects, pathology, physiopathology)
- Brain Ischemia
(drug therapy, metabolism, physiopathology)
- Carnosine
(metabolism, pharmacology, therapeutic use)
- Cell Death
(drug effects, physiology)
- Cerebral Infarction
(drug therapy, physiopathology, prevention & control)
- Cerebrovascular Circulation
(drug effects, physiology)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enzyme Activation
(drug effects, physiology)
- Free Radical Scavengers
(pharmacology, therapeutic use)
- Glutathione
(agonists, metabolism)
- Infarction, Middle Cerebral Artery
(drug therapy, metabolism, physiopathology)
- Male
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases
(metabolism)
- Mice
- Mice, Inbred C57BL
- Nerve Degeneration
(drug therapy, physiopathology, prevention & control)
- Neuroprotective Agents
(pharmacology, therapeutic use)
- Oxidative Stress
(drug effects, physiology)
- Reactive Oxygen Species
(antagonists & inhibitors, metabolism)
- Treatment Outcome
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