Duodenal intubation and aspiration test: utility in the differential diagnosis of infantile cholestasis.

Abstract

A prospective study involving 27 infants with cholestatic jaundice was carried out to evaluate the diagnostic utility of the 24-h duodenal drainage test. Extrahepatic cholestasis was confirmed by either exploratory laparotomy or autopsy in 12 of 13 cases without bile drainage, with only one false-positive result. The sensitivity of this test for extrahepatic cholestasis was 100% while the accuracy and specificity were 96.3 and 93.3%, respectively. The corresponding sensitivity, accuracy, and specificity for liver biopsy in patients with extrahepatic cholestasis were 83.3, 92.6, and 100%, respectively. It is concluded that the duodenal drainage test is a simple, rapid, and inexpensive procedure with high sensitivity and specificity in the diagnosis of infantile cholestasis.

• Authors: A G Faweya, O O Akinyinka, O Sodeinde
• Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 13 Issue 3 Pg. 290-2 (Oct 1991) ISSN: 0277-2116 [Print] United States
• PMID: 1791506 (Publication Type: Journal Article)

Topics

• Cholestasis, Extrahepatic (diagnosis)
• Cholestasis, Intrahepatic (diagnosis)
• Diagnosis, Differential
• Duodenum
• Humans
• Infant
• Infant, Newborn
• Intubation, Gastrointestinal
• Prospective Studies
• Sensitivity and Specificity
• Suction