[Annomonysvin: a new cytotoxic gamma-lactone-monotetrahydrofuranyl acetogenin from Annona montana].

Abstract

The structure of annomontacin [I], a novel monotetrayhydrofuran fatty acid gamma-lactone (acetogenin) isolated from the seeds of Amnona montana, was determined by spectral analysis. The cytotoxicities in vitro of annomontacin [I], annonacinone [2], and annonacin were measured against murine leukemia L1210, human breast adenocarcinoma MDA-MB231, and human breast carcinoma MCF7 cell lines and compared with adriamycin.

• Authors: A Jossang, B Dubaele, A Cavé, M H Bartoli, H Bériel
• Journal: Journal of natural products (J Nat Prod) 1991 Jul-Aug Vol. 54 Issue 4 Pg. 967-71 ISSN: 0163-3864 [Print] United States
• Vernacular Title: Annomontacine: une nouvelle acétogénine gamma-lactone-monotetrahydrofurannique cytotoxique de l'Annona montana.
• PMID: 1791482 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Furans
• Lactones
• annonacinone
• annomontacin
• 4-Butyrolactone

Topics

• 4-Butyrolactone (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• Animals
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification)
• Drug Screening Assays, Antitumor
• Furans (chemistry, isolation & purification, pharmacology)
• Humans
• Lactones (chemistry, isolation & purification, pharmacology)
• Magnetic Resonance Spectroscopy
• Molecular Structure
• Plants
• Spectrum Analysis
• Tumor Cells, Cultured