The crystal structure and cytotoxicity of goniodiol-7-monoacetate from Goniothalamus amuyon.

Abstract

The styrylpyrone, goniodiol-7-monoacetate [1] [6R-(7R,8R-dihydro-7-acetoxy-8-hydroxystyryl)-5, 6-dihydro-2-pyrone], has been isolated from Goniothalamus amuyon, and its detailed molecular structure has been determined by X-ray crystallographic analysis. Goniodiol-7-monoacetate showed potent (ED50 values less than 0.1 microgram/ml) cytotoxicities against KB, P-388, RPMI, and TE671 tumor cells.

• Authors: Y C Wu, C Y Duh, F R Chang, G Y Chang, S K Wang, J J Chang, D R McPhail, A T McPhail, K H Lee
• Journal: Journal of natural products (J Nat Prod) 1991 Jul-Aug Vol. 54 Issue 4 Pg. 1077-81 ISSN: 0163-3864 [Print] United States
• PMID: 1791473 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Pyrones
• Styrenes
• goniodiol-7-monoacetate

Topics

• Animals
• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification)
• Crystallization
• Drug Screening Assays, Antitumor
• Humans
• Leukemia P388 (drug therapy)
• Molecular Structure
• Plants, Medicinal
• Pyrones (chemistry, isolation & purification, pharmacology)
• Styrenes (chemistry, isolation & purification, pharmacology)
• Tumor Cells, Cultured