Two new styryl lactones, 9-deoxygoniopypyrone and 7-epi-goniofufurone, from Goniothalamus giganteus.

Abstract

Two new styryl lactones, 9-deoxygoniopypyrone [1] and 7-epi-goniofufurone [3], and a known styryl lactone, goniodiol [5], were isolated from the stem bark of Goniothalamus giganteus. The structures were elucidated by ir, ms, 1H-nmr, 13C-nmr, and 1H-1H COSY spectra; the relative configurations were determined by X-ray crystallographic analysis. Unlike goniopypyrone [2] and goniofufurone [4], neither of the new styryl lactones 1 and 3 showed significant bioactivities to human tumor cells. However, goniodiol [5] showed significant and selective cytotoxicity against human lung tumor cells (A-549).

• Authors: X P Fang, J E Anderson, C J Chang, J L McLaughlin, P E Fanwick
• Journal: Journal of natural products (J Nat Prod) 1991 Jul-Aug Vol. 54 Issue 4 Pg. 1034-43 ISSN: 0163-3864 [Print] United States
• PMID: 1791471 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents, Phytogenic
• Lactones
• 9-deoxygoniopypyrone
• 7-goniofufurone

Topics

• Animals
• Antineoplastic Agents, Phytogenic
• Artemia (drug effects)
• Crystallography
• Drug Screening Assays, Antitumor
• Humans
• Lactones (chemistry, isolation & purification, pharmacology)
• Magnetic Resonance Spectroscopy
• Molecular Structure
• Plants
• Tumor Cells, Cultured