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Studies on the synthesis of sesquiterpene lactones, 12. Synthesis of (+)-colartin, (+)-arbusculin A, and their C-4 epimers and their biological activities.

Abstract
Colartin [9] and arbusculin A [11] have been synthesized from alpha-santonin [1] in 14.5% (11 steps) and 9.3% (13 steps) overall yields, respectively. Arbusculin A [11] and compounds 20, 21, and 22, which were derived from intermediate 2, showed significant cell growth inhibitory activity against murine lymphocytic leukemia (P-388) in vitro. Plant growth regulating activity of 11 and its synthetic intermediates 4, 5, 8, and 9 was also studied.
AuthorsM Ando, K Isogai, H Azami, N Hirata, Y Yanagi
JournalJournal of natural products (J Nat Prod) 1991 Jul-Aug Vol. 54 Issue 4 Pg. 1017-24 ISSN: 0163-3864 [Print] United States
PMID1791470 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Plant Growth Regulators
  • Sesquiterpenes
  • colartin
  • arbusculin A
Topics
  • Animals
  • Antineoplastic Agents (chemical synthesis)
  • Isomerism
  • Leukemia P388 (drug therapy)
  • Molecular Structure
  • Plant Growth Regulators (chemical synthesis)
  • Sesquiterpenes (chemical synthesis, pharmacology)

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