Abstract |
Colartin [9] and arbusculin A [11] have been synthesized from alpha- santonin [1] in 14.5% (11 steps) and 9.3% (13 steps) overall yields, respectively. Arbusculin A [11] and compounds 20, 21, and 22, which were derived from intermediate 2, showed significant cell growth inhibitory activity against murine lymphocytic leukemia (P-388) in vitro. Plant growth regulating activity of 11 and its synthetic intermediates 4, 5, 8, and 9 was also studied.
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Authors | M Ando, K Isogai, H Azami, N Hirata, Y Yanagi |
Journal | Journal of natural products
(J Nat Prod)
1991 Jul-Aug
Vol. 54
Issue 4
Pg. 1017-24
ISSN: 0163-3864 [Print] United States |
PMID | 1791470
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Plant Growth Regulators
- Sesquiterpenes
- colartin
- arbusculin A
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Topics |
- Animals
- Antineoplastic Agents
(chemical synthesis)
- Isomerism
- Leukemia P388
(drug therapy)
- Molecular Structure
- Plant Growth Regulators
(chemical synthesis)
- Sesquiterpenes
(chemical synthesis, pharmacology)
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