Abstract | OBJECTIVE: METHODS: This study was a randomised, double-blind, placebo-controlled trial involving 186 presumably healthy volunteers. One hundred received a multi- antioxidant supplementation and 86 a placebo for two years. Blood zinc, selenium, beta-carotene, vitamin C and E and urinary excretion of 11-dehydro TXB(2) and 2,3 dinor 6 keto PGF(1alpha) were measured. RESULTS: Baseline subject characteristics did not differ between the two groups. Blood zinc, selenium, and beta-carotene concentrations significantly increased between baseline and two years in the multi- antioxidant supplementation group supporting subject compliance (p < 0.05). At two years, the median urinary 11-dehydro TXB(2)/2,3 dinor 6 keto PGF(1alpha) ratio was significantly lower in the multi- antioxidant supplementation group (3.4 versus 2.78, p = 0.015). Serum selenium concentration was the only antioxidant studied that was significantly related to the urinary 11-dehydro TXB(2)/2,3 dinor 6 keto PGF(1alpha) ratio. CONCLUSIONS: These results support the hypothesis that a low-dose multi- antioxidant supplementation may contributes to a reduction in platelet activation which is beneficial for cardiovascular function.
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Authors | Josiane Arnaud, Muriel Bost, Dominique Vitoux, José Labarère, Pilar Galan, Henri Faure, Serge Hercberg, Jean-Claude Bordet, Anne-Marie Roussel, Philippe Chappuis, Société Francophone d'Etudes et de Recherche sur les Eléments Toxiques et Essentiels |
Journal | Journal of the American College of Nutrition
(J Am Coll Nutr)
Vol. 26
Issue 5
Pg. 405-11
(Oct 2007)
ISSN: 0731-5724 [Print] United States |
PMID | 17914127
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Biomarkers
- Prostaglandins I
- Thromboxanes
- Trace Elements
- Vitamins
- beta Carotene
- Thromboxane B2
- 6-Ketoprostaglandin F1 alpha
- 2,3-dinor-6-ketoprostaglandin F1alpha
- 11-dehydro-thromboxane B2
- Selenium
- Zinc
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Topics |
- 6-Ketoprostaglandin F1 alpha
(analogs & derivatives, urine)
- Antioxidants
(administration & dosage, metabolism)
- Arteriosclerosis
(blood, prevention & control)
- Biomarkers
(urine)
- Dietary Supplements
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Patient Compliance
- Platelet Activation
(drug effects)
- Prostaglandins I
(urine)
- Selenium
(administration & dosage, blood)
- Thrombosis
(blood, prevention & control)
- Thromboxane B2
(analogs & derivatives, urine)
- Thromboxanes
(urine)
- Trace Elements
(administration & dosage, metabolism)
- Vitamins
(administration & dosage, metabolism)
- Zinc
(administration & dosage, blood)
- beta Carotene
(administration & dosage, blood)
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