HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites.

AbstractOBJECTIVE:
This trial evaluated the effect of antioxidant supplementation on the urinary excretion of 11-dehydro TXB(2)/2,3 dinor 6 keto PGF(1alpha) ratio, a marker of the pathogenesis of thrombosis and arteriosclerosis.
METHODS:
This study was a randomised, double-blind, placebo-controlled trial involving 186 presumably healthy volunteers. One hundred received a multi-antioxidant supplementation and 86 a placebo for two years. Blood zinc, selenium, beta-carotene, vitamin C and E and urinary excretion of 11-dehydro TXB(2) and 2,3 dinor 6 keto PGF(1alpha) were measured.
RESULTS:
Baseline subject characteristics did not differ between the two groups. Blood zinc, selenium, and beta-carotene concentrations significantly increased between baseline and two years in the multi-antioxidant supplementation group supporting subject compliance (p < 0.05). At two years, the median urinary 11-dehydro TXB(2)/2,3 dinor 6 keto PGF(1alpha) ratio was significantly lower in the multi-antioxidant supplementation group (3.4 versus 2.78, p = 0.015). Serum selenium concentration was the only antioxidant studied that was significantly related to the urinary 11-dehydro TXB(2)/2,3 dinor 6 keto PGF(1alpha) ratio.
CONCLUSIONS:
These results support the hypothesis that a low-dose multi-antioxidant supplementation may contributes to a reduction in platelet activation which is beneficial for cardiovascular function.
AuthorsJosiane Arnaud, Muriel Bost, Dominique Vitoux, José Labarère, Pilar Galan, Henri Faure, Serge Hercberg, Jean-Claude Bordet, Anne-Marie Roussel, Philippe Chappuis, Société Francophone d'Etudes et de Recherche sur les Eléments Toxiques et Essentiels
JournalJournal of the American College of Nutrition (J Am Coll Nutr) Vol. 26 Issue 5 Pg. 405-11 (Oct 2007) ISSN: 0731-5724 [Print] United States
PMID17914127 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Biomarkers
  • Prostaglandins I
  • Thromboxanes
  • Trace Elements
  • Vitamins
  • beta Carotene
  • Thromboxane B2
  • 6-Ketoprostaglandin F1 alpha
  • 2,3-dinor-6-ketoprostaglandin F1alpha
  • 11-dehydro-thromboxane B2
  • Selenium
  • Zinc
Topics
  • 6-Ketoprostaglandin F1 alpha (analogs & derivatives, urine)
  • Antioxidants (administration & dosage, metabolism)
  • Arteriosclerosis (blood, prevention & control)
  • Biomarkers (urine)
  • Dietary Supplements
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Patient Compliance
  • Platelet Activation (drug effects)
  • Prostaglandins I (urine)
  • Selenium (administration & dosage, blood)
  • Thrombosis (blood, prevention & control)
  • Thromboxane B2 (analogs & derivatives, urine)
  • Thromboxanes (urine)
  • Trace Elements (administration & dosage, metabolism)
  • Vitamins (administration & dosage, metabolism)
  • Zinc (administration & dosage, blood)
  • beta Carotene (administration & dosage, blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: