[Transient myeloproliferative disorder in a neonate without Down syndrome].

Abstract

We report a new case of transient myeloproliferative disorder (TMD) in a non Down syndrome neonate. The cytogenetic and molecular studies within from the blood blast cells identified a trisomy 21 and a partial deletion in exon 2 of the transcription factor GATA1. Spontaneous regression of the TMD was achieved at the age of 1 month as the clonal and molecular abnormalities. A survey by periodic cytological examinations of peripheral blood cells and GATA1 mutation analysis was instituted since three years and has not detected up to date acute leukaemia.

• Authors: M Adam, A Vincenot, F Gouraud, C Harvel, C Perot, M F Portnoi, E Andre-Kerneis, S Giraudier, G Leverger, R Favier
• Journal: Annales de biologie clinique (Ann Biol Clin (Paris)) 2007 Sep-Oct Vol. 65 Issue 5 Pg. 569-73 ISSN: 0003-3898 [Print] France
• Vernacular Title: Syndrome myélo-prolifératif transitoire chez un nouveau-né indemne de toute pathologie constitutionnelle.
• PMID: 17913678 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• GATA1 Transcription Factor
• GATA1 protein, human

Topics

• Diseases in Twins
• Down Syndrome (genetics)
• Exons (genetics)
• Follow-Up Studies
• GATA1 Transcription Factor (genetics)
• Gene Deletion
• Humans
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (diagnosis)
• Male
• Mutation (genetics)
• Myeloproliferative Disorders (diagnosis)
• Remission, Spontaneous
• Twins, Dizygotic